Topic Overview:

Neurons use action potentials, or spikes, to transmit information. But all spikes are not created the same way, and not all of them convey the same information. Instead, each neuron regulates spiking through a unique combination of ion channels, and spikes form the basis of many different neural codes. The Prescott lab investigates these issues using an integrative approach that incorporates dynamical systems theory, computer simulations, and electrophysiological experiments.

Prescott’s talk will focus on his group’s contribution to understanding how neurons regulate their excitability and how that regulation goes awry under conditions like neuropathic pain. He will also discuss how changes in excitability affect neural coding and the impact coding changes may have on pain perception.